Laboratory Associate/Research Associate - Protein Purification

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Company Background

Thermalin Inc. is developing a pipeline of patent pending insulin analogs that address significant unmet needs in the rapidly growing insulin market ($17B today, $70B expected worldwide by 2030).  Founded on a portfolio of new insulin analogs invented by Dr. Michael Weiss, Chairman Emeritus of Biochemistry at Case Western Reserve Medical School and Director of Therapeutic Protein Institute, Thermalin’s focus is on advancing new rapid-acting and new long-acting insulins into the market.  Thermalin’s analogs are expected to address many problems associated with diabetes management by providing faster onset, lower cancer risk, reduced weight gain, reduced damage to insulin-producing cells, sustained release, and/or unrefrigerated stability/reduced fibrillation. By addressing multiple, clinically-relevant modalities, Thermalin expects to open new competitive dimensions in the marketplace. Upon clinical validation, these benefits should put Thermalin’s new insulins in an excellent, defensible position to compete for market share.

Objectives

Assist in the purification of insulin analogs and precursors from microbial and synthetic sources

Reports to

Managing Scientist-Protein Purification

Responsibilities

  • Purify novel insulins and their precursors using established protocols
  • Characterize novel insulins using reverse-phase (RP) analytical chromatography, mass spectrometry and various other biochemical methods
  • Develop new purification schemes for insulin analogs
  • Optimize procedures and protocols to improve yield, throughput and purity
  • Perform laboratory tasks safely, rapidly, and efficiently
  • Report results in written and verbal format
  • Record results accurately and meticulously
  • Perform analytical and preparative scale RP-HPLC purification
  • Perform chromatography in column and batch mode including: HIC, SEC, IEX
  • Assist in the design of protein purification techniques 
  • Continue to improve  method to increase yield, efficiency and scale
  • Characterize insulin molecules using a variety of techniques including RP-U/HPLC, mass spectrometry, and peptide mapping
  • Report progress in summary and detail on a regular basis to colleagues and supervisors
  • Excellent “hands” in executing laboratory methods, particularly handling proteins
  • Experience using analytical HPLC, preferably reverse phase
  • Data driven decision-maker
  • Excellent project planning and time management abilities
  • Good listener.  Strong, concise, and consistent written and oral communication

Typical activities

·     Keep accurate laboratory notebooks

Skills

Personal characteristics

·    Meticulous and detail oriented, responsible & mature

·    Innovative thinker

·    Passionate, committed to excellence; driven to make projects and company succeed

·    Persistent/tenacious, proactive self-starter, thorough follow-up; problem solver 

·    Initiates change. Sense of urgency.

·    Takes responsibility. Gets things done personally as well as through others

·    Risk taker; flexible and adaptable.  Comfortable with ambiguity.

·    Collaborative; team player; sense of humor

·    Demonstrated strong ethics

Background

·    At least 1 year experience post graduation, preferably in an industry setting 

·    At least 3 distinct, observable examples where achieved meaningful excellence

·    Must have an M.S in biochemistry or related science in addition to appropriate laboratory experience

Compensation

We offer competitive salary, incentive stock options and bonus based on agreed upon milestones






Skills

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Location: Cleveland, OH
Apply for this Position
Apply at: https://thermalin.hiringthing.com/job/28741/laboratory-associate-research-associate-protein-purification