Research Associate/Industry Postdoc Protein Biochemistry

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Biophysical characterization of insulin analogs and formulations

Reports to

VP, Research & Development


·    Biophysical characterization (e.g., unformulated and formulated stability and aggregation) of insulin analogs using full spectrum of protein analytical methods: UV/Vis spectroscopy, circular dichroism, mass spectroscopy, DLS, MALS, AUC, etc.

·    Timely completion of approved studies; meet tight deadlines

·    Performing laboratory tasks safely, rapidly, accurately, independently, and efficiently

·    Leading cross-functional laboratory staff assigned to work on stability- and formulation-related projects

·    Troubleshooting equipment and assay problems quickly and independently

·    Keeping management timely informed of progress, challenges, and results

·    Recording results accurately and meticulously;

·    Reporting progress and challenges in summary and detail on a daily basis

Typical Activities

·    Formulating samples for use in various experiments and assays

·    Quantitation of insulin formulations using analytical reverse-phase HPLC/UPLC

·    Spectroscopic analysis of insulin analogs

·    Conformational and chemical stability analysis

·    Performing MS and other analyses to identify degradation products

·    Keeping accurate laboratory notebooks, and sample management documentation


·    Protein handling and analysis

·    Formulating proteins for analysis

·    Quantification of protein in solution using analytical HPLC/UPLC

·    MALDI and ESI mass spectrometry analysis including LC/MS and LC/MS-MS

·    UV spectroscopy, circular dichroism as well as other biophysical characterization methods

·    Detailed understanding of behavior of proteins in formulation

·    Adapting to changing circumstances and company priorities

·    Juggling several simultaneous projects.

·    Good listener.  Strong, concise written andoral communication

Personal Characteristics

·    Meticulous and detail oriented, responsible & mature

·    Organized project manager with drive and ambition to exceed goals and targets

·    Passionate, committed to excellence; driven to make projects and company succeed

·    Persistent/tenacious, proactive self-starter, thorough follow-up; problem solver.

·    Initiates change. Sense of urgency

·    Takes responsibility. Gets things done personally as well as through others

·    Risk taker; flexible and adaptable.  Comfortable with ambiguity

·    Good with people; team player; sense of humor

·    Demonstrated strong ethics


·    At least 3 distinct, observable examples where achieved meaningful excellence

·    Must have either a  Ph.D. or M.S. with 2+ years work experience in biochemistry or related science in addition to appropriate laboratory experience


We offer a competitive salary with bonus based on agreed upon milestones and stock options

Location: Cleveland, OH
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