Laboratory Associate/Research Associate - Protein Purification

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Objectives

Assist in the purification, characterization and tracking of insulin analogs and precursors from microbial and synthetic sources

Reports to

Department Head- Purification and Analytical Chemistry 

Responsibilities

  • Purify novel insulins and their precursors using established protocols
  • Characterize novel insulins using reverse-phase (RP) analytical chromatography, mass spectrometry and various other biochemical methods
  • Track molecule status 
  • Develop new purification schemes for insulin analogs
  • Optimize procedures and protocols to improve yield, throughput and purity
  • Perform laboratory tasks safely, rapidly, and efficiently
  • Report results in written and verbal format
  • Record results accurately and meticulously
  • Perform analytical and preparative scale RP-HPLC purification
  • Perform chromatography in column and batch mode including: HIC, SEC, IEX
  • Assist in the design of protein purification techniques 
  • Continue to improve methods to increase yield, efficiency and scale
  • Characterize insulin molecules using a variety of techniques including RP-U/HPLC, mass spectrometry, and peptide mapping 
  • Report progress in summary and detail on a regular basis to colleagues and supervisors
  • Excellent “hands” in executing laboratory methods, particularly handling proteins
  • Experience using analytical HPLC, preferably reverse phase
  • Data driven decision-maker
  • Excellent project planning and time management abilities
  • Good listener.  Strong, concise, and consistent written and oral communication

Typical activities

·     Keep accurate laboratory notebooks

Skills

Personal characteristics

·     Meticulous and detail oriented, responsible & mature

·     Innovative thinker

·     Passionate, committed to excellence; driven to make projects and company succeed

·     Persistent/tenacious, proactive self-starter, thorough follow-up; problem solver  

·     Initiates change. Sense of urgency.

·     Takes responsibility. Gets things done personally as well as through others 

·     Risk taker; flexible and adaptable.  Comfortable with ambiguity.

·     Collaborative; team player; sense of humor

·     Demonstrated strong ethics

Background

·     At least 1 year experience post graduation,  in an industry setting 

·     At least 3 distinct, observable examples where achieved meaningful excellence

·     Must have an M.S in biochemistry or related science in addition to appropriate laboratory experience

Must be eligible to work in the US.  We do not provide sponsorship

Compensation

We offer competitive salary, incentive stock options and bonus based on agreed upon milestones

Location: Cleveland, OH
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Apply at: https://thermalin.hiringthing.com/job/67630/laboratory-associate-research-associate-protein-purification